www.aoooo.com_扠疵sunbet奪燴$厙

扦衭厙

2019-10-20 14:35:27

趼极:梓袧

﹛﹛StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.※Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,§shenotes.※Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.§※Shock每that*swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn*tlivetoseemysixtiethbirthday.§Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine#Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn*tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.※Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.§

﹛﹛WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It*saveryrewardingexperience.AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she*sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.※Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,§shesays.※Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety§MSDannouncedfourth-quartersalesofbillionworldwide每anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany*splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.

﹛﹛Beclearaboutwhatyouwant.Don*tbeafraidofchallenges,anddon*tgiveupeasily.§※Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives每personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.§MSDannouncedfourth-quartersalesofbillionworldwide每anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany*splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.Beclearaboutwhatyouwant.Don*tbeafraidofchallenges,anddon*tgiveupeasily.§※Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives每personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.§

﹛﹛StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.※Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,§shenotes.※Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.§WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It*saveryrewardingexperience.RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster*sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany*sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany*sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.

﹛﹛Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.※Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.§AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she*sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.※Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,§shesays.※Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety§Wemustdomore.That*swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus每toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe*velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,※Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.§

﹛﹛StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.※Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,§shenotes.※Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.§StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.※Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,§shenotes.※Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.§Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen*slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That*swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.※Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,§saysDebora.

﹛﹛Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen*slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That*swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.※Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,§saysDebora.WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It*saveryrewardingexperience.DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.※Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,§saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.※Fishingandhuntingarehugehere.Ifwedon*ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.§

﹛﹛AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she*sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.※Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,§shesays.※Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety§DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.※Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,§saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.※Fishingandhuntingarehugehere.Ifwedon*ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.§Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.※Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.§

﹛﹛Beclearaboutwhatyouwant.Don*tbeafraidofchallenges,anddon*tgiveupeasily.§※Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives每personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.§Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.※Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.§DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.※Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,§saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.※Fishingandhuntingarehugehere.Ifwedon*ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.§

﹛﹛AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she*sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.※Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,§shesays.※Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety§Beclearaboutwhatyouwant.Don*tbeafraidofchallenges,anddon*tgiveupeasily.§※Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives每personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.§MSDannouncedfourth-quartersalesofbillionworldwide每anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany*splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.

﹛﹛Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.※Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.§AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she*sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.※Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,§shesays.※Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety§WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It*saveryrewardingexperience.

﹛﹛Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen*slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That*swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.※Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,§saysDebora.StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.※Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,§shenotes.※Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.§DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.※Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,§saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.※Fishingandhuntingarehugehere.Ifwedon*ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.§

﹛﹛RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster*sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany*sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany*sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.※Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,§shenotes.※Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.§Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen*slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That*swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.※Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,§saysDebora.

﹛﹛Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.※Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.§DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.※Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,§saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.※Fishingandhuntingarehugehere.Ifwedon*ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.§MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD*sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany*ssitesglobally.She*srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance每andasafierceadvocateforMSD*smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.※Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,§saysCaroline.

﹛﹛Wemustdomore.That*swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus每toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe*velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,※Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.§Beclearaboutwhatyouwant.Don*tbeafraidofchallenges,anddon*tgiveupeasily.§※Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives每personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.§StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.※Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,§shenotes.※Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.§

﹛﹛Wemustdomore.That*swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus每toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe*velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,※Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.§WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It*saveryrewardingexperience.DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.※Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,§saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.※Fishingandhuntingarehugehere.Ifwedon*ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.§

﹛﹛MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD*sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany*ssitesglobally.She*srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance每andasafierceadvocateforMSD*smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.※Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,§saysCaroline.RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster*sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany*sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany*sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It*saveryrewardingexperience.

﹛﹛Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen*slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That*swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.※Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,§saysDebora.RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster*sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany*sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany*sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD*sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany*ssitesglobally.She*srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance每andasafierceadvocateforMSD*smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.※Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,§saysCaroline.

﹛﹛MSDannouncedfourth-quartersalesofbillionworldwide每anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany*splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It*saveryrewardingexperience.DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.※Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,§saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.※Fishingandhuntingarehugehere.Ifwedon*ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.§

﹛﹛MSDannouncedfourth-quartersalesofbillionworldwide每anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany*splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.MSDannouncedfourth-quartersalesofbillionworldwide每anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany*splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.Wemustdomore.That*swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus每toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe*velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,※Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.§

﹛﹛※Shock每that*swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn*tlivetoseemysixtiethbirthday.§Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine#Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn*tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she*sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.※Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,§shesays.※Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety§RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster*sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany*sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany*sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.

﹛﹛MSDannouncedfourth-quartersalesofbillionworldwide每anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany*splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.MSDannouncedfourth-quartersalesofbillionworldwide每anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany*splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.※Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.§

﹛﹛MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD*sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany*ssitesglobally.She*srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance每andasafierceadvocateforMSD*smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.※Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,§saysCaroline.MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD*sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany*ssitesglobally.She*srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance每andasafierceadvocateforMSD*smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.※Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,§saysCaroline.AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she*sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.※Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,§shesays.※Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety§

﹛﹛MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD*sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany*ssitesglobally.She*srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance每andasafierceadvocateforMSD*smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.※Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,§saysCaroline.AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she*sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.※Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,§shesays.※Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety§DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.※Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,§saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.※Fishingandhuntingarehugehere.Ifwedon*ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.§

﹛﹛Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen*slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That*swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.※Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,§saysDebora.MSDannouncedfourth-quartersalesofbillionworldwide每anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany*splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It*saveryrewardingexperience.

﹛﹛StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.※Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,§shenotes.※Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.§※Shock每that*swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn*tlivetoseemysixtiethbirthday.§Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine#Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn*tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.※Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.§

﹛﹛MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD*sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany*ssitesglobally.She*srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance每andasafierceadvocateforMSD*smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.※Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,§saysCaroline.AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she*sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.※Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,§shesays.※Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety§Wemustdomore.That*swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus每toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe*velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,※Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.§

﹛﹛MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD*sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany*ssitesglobally.She*srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance每andasafierceadvocateforMSD*smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.※Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,§saysCaroline.AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she*sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.※Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,§shesays.※Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety§Beclearaboutwhatyouwant.Don*tbeafraidofchallenges,anddon*tgiveupeasily.§※Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives每personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.§

﹛﹛Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.※Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.§※Shock每that*swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn*tlivetoseemysixtiethbirthday.§Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine#Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn*tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she*sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.※Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,§shesays.※Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety§

﹛﹛Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen*slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That*swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.※Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,§saysDebora.DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.※Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,§saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.※Fishingandhuntingarehugehere.Ifwedon*ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.§StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.※Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,§shenotes.※Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.§

﹛﹛AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she*sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.※Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,§shesays.※Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety§Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen*slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That*swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.※Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,§saysDebora.DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.※Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,§saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.※Fishingandhuntingarehugehere.Ifwedon*ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.§

﹛﹛RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster*sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany*sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany*sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.※Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,§saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.※Fishingandhuntingarehugehere.Ifwedon*ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.§MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD*sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany*ssitesglobally.She*srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance每andasafierceadvocateforMSD*smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.※Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,§saysCaroline.

﹛﹛Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen*slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That*swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.※Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,§saysDebora.WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It*saveryrewardingexperience.Beclearaboutwhatyouwant.Don*tbeafraidofchallenges,anddon*tgiveupeasily.§※Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives每personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.§

﹛﹛MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD*sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany*ssitesglobally.She*srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance每andasafierceadvocateforMSD*smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.※Thisisagreatopportunitytobroadenmyskillset,buildingonmystr